The Office of Interagency Affairs includes advocates who pursue regulatory, legislative, and other policy initiatives that support small business growth. The office prepares comment letters and testimony on federal proposals that may affect small firms. The hallmark of Advocacy's efforts is addressing concerns shared by small businesses of all types. These include access to capital, burdens of regulatory compliance, costs associated with telecommunications reform, and tax policies that do not fit small firm operations. In addition, the Office of Interagency Affairs tackles regulatory issues that affect specific industries.

In pursuing good public policy, Advocacy's Office of Interagency Affairs also monitors federal agencies' compliance with the Regulatory Flexibility Act (RFA), as amended by the Small Business Regulatory Enforcement Fairness Act. The RFA requires federal agencies to analyze the impact of proposed regulations on small firms, and the Office of Advocacy reports on agencies' compliance to Congress each year.